Japanese team plans to use iPS cells in clinical trial for cancer patients

A Japanese team is preparing a clinical trial to inject immune cells made from induced pluripotent stem (iPS) cells into patients with head and neck cancer, it has been learned.

The team of Riken and Chiba University researchers will file for state approval of the trial as early as autumn and start as soon as approval is given, informed sources said Thursday. The trial would become the first in Japan to use iPS cells as a possible cancer treatment.

Key members of the team include Haruhiko Koseki, executive of the Riken Center for Integrative Medical Sciences, and Chiba University professor Yoshitaka Okamoto.

The trial is expected to be conducted on three patients with recurrent cancers that cannot be sufficiently treated through surgery.

13 'harmed' by surgeons

An NHS Trust has apologised after 13 cancer patients suffered physical harm following reconstructive surgery.

Leicester Royal Infirmary's maxillofacial surgery service helped people following head and neck cancer.

Patients who used the service between 2009 and 2016 have since had problems eating, swallowing and talking.

The service was suspended in November 2016 following a visit from the Royal College of Surgeons, after dental trainees raised safety concerns.

The hospital has since contacted 101 people who had surgery in that seven-year period who might have been harmed; 13 of whom said they felt they had "definitely suffered physical harm".

Why People with HIV Have Higher Cancer Risk

New study revealed how the virus could affect cancer cells.

Share on PinterestResearchers are learning more about how HIV can impact cancer risk. Getty Images

A new study shows how tiny intercellular bubbles may play a big role in altering the growth and spread of cancer in people who are HIV positive.

Researchers with the Case Western Reserve University’s School of Dental Medicine studied 18 HIV-positive people with head and neck cancer, and found that exosomes or nanocarriers that transfer DNA, RNA, and proteins to cells, also promote cancer cells.

As a result, this new research may show why cancer grows faster and more aggressively in patients with HIV, said Ge Jin, PhD, associate professor of biological sciences at the School of Dental Medicine and the study’s author and principal investigator.

“The cells in question release exosomes into the bloodstream — think small nanoparticles — that don’t cause cancer, but they support it,” Jin said. “There are big implications here.”

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